Showing posts with label skin cancer. Show all posts
Showing posts with label skin cancer. Show all posts

Thursday, October 7, 2010

Survey: People Are Not Examining Their Skin for Signs of Cancer

SCHAUMBURG, Ill., May 17 / -- Despite the fact that skin cancer is the only cancer that can be seen on the surface of the skin, a new survey by the American Academy of Dermatology (Academy) reports that a large number of people are not taking the time to examine their skin for any changes that could be warning signs of skin cancer or seeing a health-care provider for a skin cancer screening.

The "Suntelligence: How Sun Smart is Your City?" online survey polled more than 7,000 adults nationwide to determine their knowledge, attitudes and behaviors toward tanning, sun protection and skin cancer detection. Twenty-six cities were ranked based on respondents' answers to several questions in each category.

"Each year, substantially more than 1 million cases of skin cancer are diagnosed in the United States," said dermatologist Zoe D. Draelos, MD, FAAD, consulting professor at Duke University School of Medicine, Durham, N.C. "Like many cancers, skin cancer is highly treatable if caught early before it spreads. In fact, studies show that the five-year survival rate for people whose melanoma is detected and treated before it spreads to the lymph nodes is 99 percent – making early detection essential."

However, the survey found that more than one-quarter (28 percent) of all respondents indicated never examining their skin for changes to moles and other skin blemishes. Analyzing the data by gender and age, more men (32 percent) than women (25 percent) indicated that they never examine their skin. In addition, more young adults 18-29 years old (32 percent) reported never examining their skin than any other age group.

When asked about getting screened for skin cancer by a health-care provider, about three in five respondents (59 percent) had never been examined. More young adults age 18-29 (69 percent) reported never getting screened for skin cancer by a health-care provider.

"The fact that younger people are not getting screened for skin cancer is alarming, especially since research shows that melanoma – the most serious form of skin cancer – is the most common form of cancer for young adults 25-29 years old and the second most common form of cancer for adolescents and young adults 15-29 years old," said Dr. Draelos.

To help people of all ages spot any new or developing lesions that could be potential warning signs of skin cancer, the Academy recommends periodic self-examinations of the entire body (including hard-to-reach spots). Dr. Draelos added that enlisting the help of a loved one can be beneficial in monitoring changes in the skin and spotting skin cancer.

"Studies show that involving a partner in the self-examination process and having regular screenings by a health-care provider can improve the early detection of skin cancer," explained Dr. Draelos. "These types of regular screenings could lead to fewer deaths if skin cancer is caught early in its most treatable stages."

To enhance a patient's ability to detect skin cancer, the Academy advises learning the ABCDEs of Melanoma Detection. The following are characteristics of moles for which individuals should check their skin:

Asymmetry (one half unlike the other half)
Border (irregular, scalloped or poorly defined)
Color (varies from one area to another; shades of tan and brown, black; sometimes white, red or blue)
Diameter (the size of a pencil eraser or larger)
Evolving (changing in size, shape or color)

"A mole with any of these characteristics, or one that is an 'ugly duckling', meaning it looks different from the rest, should be brought to a dermatologist's attention," said Dr. Draelos.

In addition, the Academy offers a body mole map, a tool individuals can use to track their moles. The map provides information on how to perform a skin exam, images of the ABCDEs of Melanoma Detection and space for people to track their moles to determine any changes over time.

May is Melanoma/Skin Cancer Detection and Prevention Month®. This year also marks the 25th anniversary of the Academy's National Melanoma/Skin Cancer Screening Program. Since the program's inception in 1985, dermatologists have volunteered to conduct more than 2 million free skin cancer screenings across the country and detected more than 200,000 suspicious lesions. Visit www.melanomamonday.org to take the Academy's "Suntelligence" survey, as well as to find out how to perform a skin self-exam, download a body mole map or find free skin cancer screenings in your area.

The "Suntelligence" survey was conducted for the Academy by RH Research of Chicago from January 12 to January 31, 2010. A total of 7,116 respondents completed the online survey; more than 200 completes were conducted in each of the 26 selected MSAs (metropolitan statistical area) and an additional 1,123 completes were conducted in the U.S. outside of the MSAs. The survey's margin of error was + /- 1.2 percent for national data and +/- 6.9 percent for results stratified by MSA.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 16,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails. For more information, contact the Academy at 1-888-462-DERM (3376) or www.aad.org.


SOURCE American Academy of Dermatology
http://www.dermahealthinstitute.com

Wednesday, September 15, 2010

Concerned About Skin Cancer But Don't Understand Tanning Risks

SCHAUMBURG, Ill., May 10 /PRNewswire-USNewswire/ -- When it comes to tanning, dermatologists have long suspected that most people need an attitude adjustment. Now, results of a new survey by the American Academy of Dermatology (Academy) confirmed that the majority of people still idolize the bronzed look of a tan despite wanting to protect themselves from skin cancer.

For more nformation about Derma Health Intstitute, see:
http://www.dermahealthinstitute.com

The "Suntelligence: How Sun Smart is Your City?" online survey polled more than 7,000 adults nationwide to determine their knowledge, attitudes and behaviors toward tanning, sun protection and skin cancer detection. Twenty-six cities were ranked based on respondents' answers to several questions in each category.

"Our survey highlighted the contradictory feelings that many people have about tanning – they like the way a tan looks but are concerned about skin cancer, which is estimated to affect about one in five Americans in their lifetime," said dermatologist Zoe D. Draelos, MD, FAAD, consulting professor at Duke University School of Medicine, Durham, N.C. "What they may not realize is that no matter whether you tan or burn, a tan from the sun or tanning beds damages the skin and can cause wrinkles, age spots and skin cancer. The challenge is changing the long-standing attitudes about tanning to correlate with people's knowledge about skin cancer."

In examining the survey data, Dr. Draelos noted that 72 percent of all respondents agreed that people look more attractive with a tan. In addition, more men than women (76 percent vs. 68 percent, respectively) agreed with that statement.

Similarly, 66 percent of all respondents agreed that people look healthier with a tan. Once again more men than women (70 percent vs. 62 percent, respectively) agreed with this statement.

When asked whether or not they believed that sun exposure is good for your health, 60 percent of all respondents mistakenly agreed with this statement. Analyzing the data by gender, more men than women (62 percent vs. 58 percent, respectively) incorrectly thought that sun exposure is good for your health.

"Various reports touting the potential health benefits of sun exposure for vitamin D production are misleading people to believe that exposing oneself to UV radiation – which causes cancer – to prevent another disease is somehow beneficial," said Dr. Draelos. "In fact, the Academy does not recommend getting vitamin D from any form of UV exposure because UV radiation from the sun and tanning beds can lead to the development of skin cancer. Getting vitamin D from a healthy diet, which includes naturally enriched vitamin D foods, fortified foods and beverages, and/or vitamin supplements is a healthier alternative because it provides the exact same benefit without the skin cancer risk."

Dr. Draelos added that despite their positive attitudes about tanning, the majority of respondents expressed strong opinions on protecting themselves from skin cancer. For example, 75 percent of all respondents said they will do anything possible to prevent skin cancer. Furthermore, 80 percent of respondents expressed concern about skin cancer and feel it is important to protect themselves.

"When it comes to preventing skin cancer, actions speak louder than words," said Dr. Draelos. "So while it is encouraging that most people are concerned about skin cancer and want to reduce their risk of developing it, clearly more work needs to be done to change attitudes on tanning. If a person likes the look of a tan, he or she should consider using a self-tanner but use sunscreen with it."

May is Melanoma/Skin Cancer Detection and Prevention Month®. Visit www.melanomamonday.org to take the Academy's "Suntelligence" survey, as well as to find out how to perform a skin self-exam, download a body mole map or find free skin cancer screenings in your area.

The "Suntelligence" survey was conducted for the Academy by RH Research of Chicago from January 12 to January 31, 2010. A total of 7,116 respondents completed the online survey; more than 200 completes were conducted in each of the 26 selected

MSAs (metropolitan statistical area) and an additional 1,123 completes were conducted in the U.S. outside of the MSAs. The survey's margin of error was +/- 1.2 percent for national data and +/- 6.9 percent for results stratified by MSA.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 16,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails. For more information, contact the Academy at 1-888-462-DERM (3376) or www.aad.org.

Editor's Note: Key highlights of the "Suntelligence: How Sun Smart is Your City?" survey and a complete listing of the 26 most and least sun-smart cities are available at www.aad.org/media.

SOURCE American Academy of Dermatology

Wednesday, July 29, 2009

Early Detection of Melanoma is Vital For Beating Disease

SCHAUMBURG, Ill., May 4 /PRNewswire-USNewswire/ -- On television's popular "Grey's Anatomy," Dr. Izzie Stevens faces a grim diagnosis: stage IV metastatic melanoma. As the drama unfolds, viewers get a glimpse at why patients with the deadliest form of skin cancer -- in the most advanced stage of diagnosis -- face a mere 10-month median survival rate. In real life, this type of prognosis is devastating and leaves melanoma patients with few options for beating this disease that claims the life of one American almost every hour (every 62 minutes). But dermatologists agree that when melanoma is diagnosed in its earliest, most treatable stages, time is on your side.

http://www.dermahealthinstitute.com

Dermatologist Gary S. Rogers, MD, FAAD, professor of dermatology and surgery at Tufts University School of Medicine in Boston, and dermatologist Jason K. Rivers, MD, FAAD, clinical professor of dermatology at the University of British Columbia in Vancouver, reviewed the most common treatments for the different stages of melanoma and offered suggestions for melanoma patients aiming for their five-year survival mark.

Melanoma Treatments Vary Depending on Stage

When detected in its earliest stages (stage 0 - stage I), melanoma is highly curable. In fact, the American Cancer Society estimates that the average five-year survival rate for individuals whose melanoma is localized and has not spread beyond the outer layers of the skin is 99 percent. Dr. Rogers explained that for patients diagnosed with a stage 0 or stage I melanoma, a routine, typically office-based surgical procedure to remove the tumor and a margin of normal-looking skin around it is performed and neither chemotherapy nor radiation is required.

In special circumstances where a melanoma occurs on a cosmetically or functionally critical site, such as the lip, nose, eyelid or finger, Dr. Rogers noted that a new technology based on a variation of Mohs surgery is being used successfully. The procedure uses an anti-melanoma targeted antibody known as MART-1 (Melanoma Antigen Recognized by T cells), which improves the speed and accuracy of the procedure. The technique allows the surgeon to microscopically identify and remove the melanoma cells with minimal sacrifice of healthy tissues in real-time (16-20 minutes). The ability to successfully resect (or surgically remove) the cancer with potentially an 1/8 inch margin rather than an inch margin is critical when working on delicate structures such as an eyelid, said Rogers.

For stage II melanomas, surgery is performed to remove the tumor and surrounding tissue. In addition, the dermatologic surgeon often tests the lymph nodes to determine if the cancer has spread. If the melanoma is going to spread, Dr. Rogers noted that 57 percent of the time the first place the cancer goes is to the local draining lymph nodes. A procedure known as a sentinel lymph node biopsy tests the first lymph nodes into which the melanoma drains. If the lymph nodes are free of cancer cells, then the melanoma is considered in stage II with an average five-year survival rate of 70 percent. In this stage, Dr. Rogers explained that interferon may be given as an adjuvant (or drug-enhancing agent) to boost the patient's immune system.

However, if the lymph nodes are determined to be involved, then the melanoma is classified as stage III. In this stage, the cancer has spread to one or more nearby lymph nodes and the average five-year survival rate drops to 50 percent or less. Once a melanoma has spread beyond the skin growth, a more extensive treatment plan -- which may include surgical removal of the tumor with wide margins, usually including the affected regional lymph nodes; chemotherapy; immunotherapy or radiation therapy -- is often indicated.

When the tumor has spread to a distant site, such as the lung, brain or other organ, this is considered a stage IV melanoma with an average survival rate of only 10 months. One drug being used to treat patients with advanced melanoma is known as dacarbazine or DTIC. However, the remission rate with this drug is only 10 percent.

"No studies to date show that chemotherapy or any treatment regimens are effective when melanoma has spread to other organs," said Dr. Rogers. "The silver lining is that given the explosion in our understanding of the molecular biology of melanoma, there are a number of drugs and therapies in the pipeline that are being studied to treat the more advanced stage melanomas."

One potential therapy involves targeting specific drugs to specific genes that are known to go awry in the development of melanoma. There are multiple genes involved in melanoma progression from local tumor to disseminated disease. And, on a molecular level, there are many differences between melanomas that form in chronically sun-exposed areas versus areas of the body that are not sun-exposed, such as the soles or palms. The goal is to find a drug that will target a specific type of gene defect responsible for certain types of melanoma. "Just as one shoe does not fit all sizes, we are on the verge of being able to tailor therapy to a particular patient," added Dr. Rogers.

Clinical trials also are underway to test a vaccine known as the MAGE-A (melanoma antigen - family A) vaccine that would be used as an adjuvant to treat certain types of stage III and IV melanoma. MAGE is an antigen that exists in every cell in the body, but it is not expressed (or made apparent as an observable inherited characteristic) except in cancer. The gene that produces the MAGE protein lies dormant but becomes activated on the surface of melanoma cells and other cancers. Now, this vaccine is being tested to target cells that express or produce inherited characteristics of the MAGE antigen. Dr. Rogers estimated that 60 to 70 percent of melanoma patients express the MAGE antigen, and he believes the vaccine could hold tremendous promise in treating more advanced melanomas in the future.

Tips for Melanoma Survivors: Remain Vigilant

Individuals diagnosed with melanoma are at risk for developing another melanoma and other types of cancer. Dr. Rivers explained that melanoma patients, especially those with atypical moles, are at increased risk for melanoma of the eyes. He reported that studies also show that melanoma seems to increase the likelihood of contracting breast cancer and possibly some lymphomas. In families where more than one family member has melanoma, Dr. Rivers said these patients also are at increased risk for developing pancreatic cancer.

"Once a patient is diagnosed with melanoma, he or she should be checked by a dermatologist as often as every three months to once a year, depending on the individual's prognosis," said Dr. Rivers. "The most important factor in beating melanoma and improving survival rates is increased public awareness, as this has been shown to save lives by identifying melanoma at an early, curable stage."

In his practice, Dr. Rogers offers tips for melanoma survivors that he personally believes are good for their overall health. These include:

Eating foods rich in anti-oxidants, such as legumes, kale, green leafy vegetables, carrots, fish (especially salmon), fruits, whole grains, and flax seed.
Taking recommended daily doses of anti-oxidant supplements, including beta carotene, selenium, vitamin C, vitamin E and fish oils (also known as EPA).
Drink one to two glasses of red wine a day. Resveratrol, a polyphenol found in the skins of grapes (part of the plant's immune system), has potent anti-cancer properties and becomes concentrated in red wine during the fermentation process.
Avoiding other forms of alcohol other than red wine, as alcohol in general is detrimental to a person's health in many ways and suppresses the immune system.

"I always tell my melanoma patients to remain hopeful and vigilant, and see your dermatologist regularly," added Dr. Rogers. "Even if you beat melanoma once, you have an increased risk of getting another one in the future. With melanoma, you can never let your guard down."

Visit www.melanomamonday.org to find out how to perform a skin self-exam, download a body mole map to track changes in your skin and find free skin cancer screenings in your area. For more information on skin cancer, go to the "SkinCancerNet" section of www.skincarephysicians.com, a Web site developed by dermatologists that provides patients with up-to-date information on the treatment and management of disorders of the skin, hair and nails.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 15,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails. For more information, contact the Academy at 1-888-462-DERM (3376) or www.aad.org.

Source: American Academy of Dermatology

Dermatologists Encourage People to Screen for Skin Cancer

American Academy of Dermatology introduces new "E" tool for detecting melanoma

SCHAUMBURG, Ill., May 4 /PRNewswire-USNewswire/ -- Treating moms and dads to brunch or backyard barbeques is a great way to honor them on Mother's Day and Father's Day, but the American Academy of Dermatology (Academy) hopes more families will start another annual tradition -- screening their loved ones for skin cancer. To help detect the warning signs of skin cancer, especially melanoma (the deadliest form of skin cancer), the Academy is adopting the revised ABCDs of Melanoma Detection by adding an "E" for evolving.

Based on current estimates, more than 1 million cases of skin cancer will be diagnosed in the United States in 2009. When detected early, most skin cancers can be successfully treated. Performing regular skin self-examinations is an easy way to detect suspicious moles that could be cancerous, and research shows that involving a partner in the self-examination process can improve the early detection of skin cancer.

"People who check their skin regularly for any changes in existing moles or new moles are taking an important first step in detecting the early warning signs of skin cancer," said dermatologist David M. Pariser, MD, FAAD, president of the Academy. "Asking a partner to help monitor your skin for any changes or to assist in examining hard-to-reach areas can be very beneficial in spotting skin cancer."

To enhance a patient's ability to detect skin cancer, the Academy has adopted the revised ABCDs of Melanoma Detection, which include an "E" for Evolving. A mole or skin lesion that is "Evolving" or changing in size, shape or color should be brought to the attention of a dermatologist. This is in addition to other characteristics of moles for which individuals should check their skin -- Asymmetry (one half unlike the other half), Border (irregular, scalloped or poorly defined), Color (varies from one area to another; shades of tan and brown, black; sometimes white, red or blue), and Diameter (the size of a pencil eraser or larger). A mole with any of these characteristics, or one that is an "ugly duckling", meaning it looks different from the rest, should be brought to a dermatologist's attention.

A new study published in Cancer (December 15, 2008) examining changes in melanomas diagnosed over 35 years found that melanomas were frequently described by patients as evolving lesions. In this collaborative study conducted at the NYU Langone Medical Center, dermatologist David Polsky, MD, PhD, FAAD, associate professor of dermatology and pathology and director of the Pigmented Lesion Clinic in the Ronald O. Perlman Department of Dermatology, and colleagues studied 1,684 prospectively enrolled patients diagnosed with 1,734 melanomas. They observed important differences in the clinical behavior of nodular melanomas (very rapidly growing melanomas) compared to superficial spreading melanomas (the most common type of melanoma).

Among the key findings, Dr. Polsky reported that more than 90 percent of patients with nodular melanoma reported a history of change in the lesion and these patients were more likely to be diagnosed with thicker, more dangerous tumors. By comparison, 80 percent of patients with superficial spreading melanoma indicated a slower pace of change in the lesion, and over time these lesions were diagnosed earlier in their evolution, as thinner, less problematic, tumors.

"Nodular melanomas typically do not have the classic ABCD features that one might expect to find when doing a skin self-exam, as they can be one color and have smooth borders," said Dr. Polsky. "But what's important to note is that nodular melanomas do change over a few months time, especially in color or height, such as a bump on the skin. So, I think by modifying our detection criteria to include 'evolving,' the ABCDEs of Melanoma Detection will better encompass the characteristics of aggressive nodular melanomas and help patients better assess a dangerous mole."

In addition, the Academy offers a Body Mole Map, a tool individuals can use to track their moles. The map provides information on how to perform a skin exam, images of the ABCDEs of melanoma and space for people to track their moles to determine any changes over time. Popular holidays, such as Mother's Day (May 10), Father's Day (June 21) and Grandparents Day (September 13) are reminders for people to check their loved ones' skin for suspicious moles using the Academy's Body Mole Map. The mole map is available at www.melanomamonday.org.

To minimize your risk of skin cancer, the Academy recommends that everyone Be Sun Smart(SM):

Generously apply a broad-spectrum water-resistant sunscreen with a Sun Protection Factor (SPF) of at least 15 to all exposed skin. "Broad-spectrum" provides protection from both ultraviolet A (UVA) and ultraviolet B (UVB) rays. Re-apply every two hours, even on cloudy days, and after swimming or sweating. Look for the AAD SEAL OF RECOGNITION(R) on products that meet these criteria.
Wear protective clothing, such as a long-sleeved shirt, pants, a wide-brimmed hat and sunglasses, when possible.
Seek shade when appropriate, remembering that the sun's rays are strongest between 10 a.m. and 4 p.m. If your shadow is shorter than you are, seek shade.
Protect children from sun exposure by playing in the shade, using protective clothing, and applying sunscreen.
Use extra caution near water, snow and sand as they reflect the damaging rays of the sun which can increase your chance of sunburn. Get vitamin D safely through a healthy diet that may include vitamin supplements. Don't seek the sun.
Avoid tanning beds. Ultraviolet light from the sun and tanning beds can cause skin cancer and wrinkling. If you want to look like you've been in the sun, consider using a sunless self-tanning product, but continue to use sunscreen with it. Check your birthday suit on your birthday. If you notice anything changing, growing, or bleeding on your skin, see a dermatologist. Skin cancer is very treatable when caught early.
For more information about skin cancer, please visit the SkinCancerNet section of www.SkinCarePhysicians.com, a Web site developed by dermatologists that provides patients with up-to-date information on the treatment and management of disorders of the skin, hair and nails.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 15,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails. For more information, contact the Academy at 1-888-462-DERM (3376) or www.aad.org.

Source: American Academy of Dermatology

http://www.dermahealthinstitute.com

Friday, May 22, 2009

Dermatologists Encourage People to Screen for Skin Cancer

American Academy of Dermatology introduces new "E" tool for detecting melanoma

http://www.dermahealthinstitute.com

SCHAUMBURG, Ill., May 4 /PRNewswire-USNewswire/ -- Treating moms and dads to brunch or backyard barbeques is a great way to honor them on Mother's Day and Father's Day, but the American Academy of Dermatology (Academy) hopes more families will start another annual tradition -- screening their loved ones for skin cancer. To help detect the warning signs of skin cancer, especially melanoma (the deadliest form of skin cancer), the Academy is adopting the revised ABCDs of Melanoma Detection by adding an "E" for evolving.

Based on current estimates, more than 1 million cases of skin cancer will be diagnosed in the United States in 2009. When detected early, most skin cancers can be successfully treated. Performing regular skin self-examinations is an easy way to detect suspicious moles that could be cancerous, and research shows that involving a partner in the self-examination process can improve the early detection of skin cancer.

"People who check their skin regularly for any changes in existing moles or new moles are taking an important first step in detecting the early warning signs of skin cancer," said dermatologist David M. Pariser, MD, FAAD, president of the Academy. "Asking a partner to help monitor your skin for any changes or to assist in examining hard-to-reach areas can be very beneficial in spotting skin cancer."

To enhance a patient's ability to detect skin cancer, the Academy has adopted the revised ABCDs of Melanoma Detection, which include an "E" for Evolving. A mole or skin lesion that is "Evolving" or changing in size, shape or color should be brought to the attention of a dermatologist. This is in addition to other characteristics of moles for which individuals should check their skin -- Asymmetry (one half unlike the other half), Border (irregular, scalloped or poorly defined), Color (varies from one area to another; shades of tan and brown, black; sometimes white, red or blue), and Diameter (the size of a pencil eraser or larger). A mole with any of these characteristics, or one that is an "ugly duckling", meaning it looks different from the rest, should be brought to a dermatologist's attention.

A new study published in Cancer (December 15, 2008) examining changes in melanomas diagnosed over 35 years found that melanomas were frequently described by patients as evolving lesions. In this collaborative study conducted at the NYU Langone Medical Center, dermatologist David Polsky, MD, PhD, FAAD, associate professor of dermatology and pathology and director of the Pigmented Lesion Clinic in the Ronald O. Perlman Department of Dermatology, and colleagues studied 1,684 prospectively enrolled patients diagnosed with 1,734 melanomas. They observed important differences in the clinical behavior of nodular melanomas (very rapidly growing melanomas) compared to superficial spreading melanomas (the most common type of melanoma).

Among the key findings, Dr. Polsky reported that more than 90 percent of patients with nodular melanoma reported a history of change in the lesion and these patients were more likely to be diagnosed with thicker, more dangerous tumors. By comparison, 80 percent of patients with superficial spreading melanoma indicated a slower pace of change in the lesion, and over time these lesions were diagnosed earlier in their evolution, as thinner, less problematic, tumors.

"Nodular melanomas typically do not have the classic ABCD features that one might expect to find when doing a skin self-exam, as they can be one color and have smooth borders," said Dr. Polsky. "But what's important to note is that nodular melanomas do change over a few months time, especially in color or height, such as a bump on the skin. So, I think by modifying our detection criteria to include 'evolving,' the ABCDEs of Melanoma Detection will better encompass the characteristics of aggressive nodular melanomas and help patients better assess a dangerous mole."

In addition, the Academy offers a Body Mole Map, a tool individuals can use to track their moles. The map provides information on how to perform a skin exam, images of the ABCDEs of melanoma and space for people to track their moles to determine any changes over time. Popular holidays, such as Mother's Day (May 10), Father's Day (June 21) and Grandparents Day (September 13) are reminders for people to check their loved ones' skin for suspicious moles using the Academy's Body Mole Map. The mole map is available at www.melanomamonday.org.

To minimize your risk of skin cancer, the Academy recommends that everyone Be Sun Smart(SM):

Generously apply a broad-spectrum water-resistant sunscreen with a Sun Protection Factor (SPF) of at least 15 to all exposed skin. "Broad-spectrum" provides protection from both ultraviolet A (UVA) and ultraviolet B (UVB) rays. Re-apply every two hours, even on cloudy days, and after swimming or sweating. Look for the AAD SEAL OF RECOGNITION(R) on products that meet these criteria.
Wear protective clothing, such as a long-sleeved shirt, pants, a wide-brimmed hat and sunglasses, when possible.
Seek shade when appropriate, remembering that the sun's rays are strongest between 10 a.m. and 4 p.m. If your shadow is shorter than you are, seek shade.
Protect children from sun exposure by playing in the shade, using protective clothing, and applying sunscreen.
Use extra caution near water, snow and sand as they reflect the damaging rays of the sun which can increase your chance of sunburn. Get vitamin D safely through a healthy diet that may include vitamin supplements. Don't seek the sun.
Avoid tanning beds. Ultraviolet light from the sun and tanning beds can cause skin cancer and wrinkling. If you want to look like you've been in the sun, consider using a sunless self-tanning product, but continue to use sunscreen with it. Check your birthday suit on your birthday. If you notice anything changing, growing, or bleeding on your skin, see a dermatologist. Skin cancer is very treatable when caught early.
For more information about skin cancer, please visit the SkinCancerNet section of www.SkinCarePhysicians.com, a Web site developed by dermatologists that provides patients with up-to-date information on the treatment and management of disorders of the skin, hair and nails.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 15,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails. For more information, contact the Academy at 1-888-462-DERM (3376) or www.aad.org.

Source: American Academy of Dermatology

http://www.dermahealthinstitute.com

Early Detection of Melanoma is Vital For Beating Disease

http://www.dermahealthinstitute.com

SCHAUMBURG, Ill., May 4 /PRNewswire-USNewswire/ -- On television's popular "Grey's Anatomy," Dr. Izzie Stevens faces a grim diagnosis: stage IV metastatic melanoma. As the drama unfolds, viewers get a glimpse at why patients with the deadliest form of skin cancer -- in the most advanced stage of diagnosis -- face a mere 10-month median survival rate. In real life, this type of prognosis is devastating and leaves melanoma patients with few options for beating this disease that claims the life of one American almost every hour (every 62 minutes). But dermatologists agree that when melanoma is diagnosed in its earliest, most treatable stages, time is on your side.

Dermatologist Gary S. Rogers, MD, FAAD, professor of dermatology and surgery at Tufts University School of Medicine in Boston, and dermatologist Jason K. Rivers, MD, FAAD, clinical professor of dermatology at the University of British Columbia in Vancouver, reviewed the most common treatments for the different stages of melanoma and offered suggestions for melanoma patients aiming for their five-year survival mark.

Melanoma Treatments Vary Depending on Stage

When detected in its earliest stages (stage 0 - stage I), melanoma is highly curable. In fact, the American Cancer Society estimates that the average five-year survival rate for individuals whose melanoma is localized and has not spread beyond the outer layers of the skin is 99 percent. Dr. Rogers explained that for patients diagnosed with a stage 0 or stage I melanoma, a routine, typically office-based surgical procedure to remove the tumor and a margin of normal-looking skin around it is performed and neither chemotherapy nor radiation is required.

In special circumstances where a melanoma occurs on a cosmetically or functionally critical site, such as the lip, nose, eyelid or finger, Dr. Rogers noted that a new technology based on a variation of Mohs surgery is being used successfully. The procedure uses an anti-melanoma targeted antibody known as MART-1 (Melanoma Antigen Recognized by T cells), which improves the speed and accuracy of the procedure. The technique allows the surgeon to microscopically identify and remove the melanoma cells with minimal sacrifice of healthy tissues in real-time (16-20 minutes). The ability to successfully resect (or surgically remove) the cancer with potentially an 1/8 inch margin rather than an inch margin is critical when working on delicate structures such as an eyelid, said Rogers.

For stage II melanomas, surgery is performed to remove the tumor and surrounding tissue. In addition, the dermatologic surgeon often tests the lymph nodes to determine if the cancer has spread. If the melanoma is going to spread, Dr. Rogers noted that 57 percent of the time the first place the cancer goes is to the local draining lymph nodes. A procedure known as a sentinel lymph node biopsy tests the first lymph nodes into which the melanoma drains. If the lymph nodes are free of cancer cells, then the melanoma is considered in stage II with an average five-year survival rate of 70 percent. In this stage, Dr. Rogers explained that interferon may be given as an adjuvant (or drug-enhancing agent) to boost the patient's immune system.

However, if the lymph nodes are determined to be involved, then the melanoma is classified as stage III. In this stage, the cancer has spread to one or more nearby lymph nodes and the average five-year survival rate drops to 50 percent or less. Once a melanoma has spread beyond the skin growth, a more extensive treatment plan -- which may include surgical removal of the tumor with wide margins, usually including the affected regional lymph nodes; chemotherapy; immunotherapy or radiation therapy -- is often indicated.

When the tumor has spread to a distant site, such as the lung, brain or other organ, this is considered a stage IV melanoma with an average survival rate of only 10 months. One drug being used to treat patients with advanced melanoma is known as dacarbazine or DTIC. However, the remission rate with this drug is only 10 percent.

"No studies to date show that chemotherapy or any treatment regimens are effective when melanoma has spread to other organs," said Dr. Rogers. "The silver lining is that given the explosion in our understanding of the molecular biology of melanoma, there are a number of drugs and therapies in the pipeline that are being studied to treat the more advanced stage melanomas."

One potential therapy involves targeting specific drugs to specific genes that are known to go awry in the development of melanoma. There are multiple genes involved in melanoma progression from local tumor to disseminated disease. And, on a molecular level, there are many differences between melanomas that form in chronically sun-exposed areas versus areas of the body that are not sun-exposed, such as the soles or palms. The goal is to find a drug that will target a specific type of gene defect responsible for certain types of melanoma. "Just as one shoe does not fit all sizes, we are on the verge of being able to tailor therapy to a particular patient," added Dr. Rogers.

Clinical trials also are underway to test a vaccine known as the MAGE-A (melanoma antigen - family A) vaccine that would be used as an adjuvant to treat certain types of stage III and IV melanoma. MAGE is an antigen that exists in every cell in the body, but it is not expressed (or made apparent as an observable inherited characteristic) except in cancer. The gene that produces the MAGE protein lies dormant but becomes activated on the surface of melanoma cells and other cancers. Now, this vaccine is being tested to target cells that express or produce inherited characteristics of the MAGE antigen. Dr. Rogers estimated that 60 to 70 percent of melanoma patients express the MAGE antigen, and he believes the vaccine could hold tremendous promise in treating more advanced melanomas in the future.

Tips for Melanoma Survivors: Remain Vigilant

Individuals diagnosed with melanoma are at risk for developing another melanoma and other types of cancer. Dr. Rivers explained that melanoma patients, especially those with atypical moles, are at increased risk for melanoma of the eyes. He reported that studies also show that melanoma seems to increase the likelihood of contracting breast cancer and possibly some lymphomas. In families where more than one family member has melanoma, Dr. Rivers said these patients also are at increased risk for developing pancreatic cancer.

"Once a patient is diagnosed with melanoma, he or she should be checked by a dermatologist as often as every three months to once a year, depending on the individual's prognosis," said Dr. Rivers. "The most important factor in beating melanoma and improving survival rates is increased public awareness, as this has been shown to save lives by identifying melanoma at an early, curable stage."

In his practice, Dr. Rogers offers tips for melanoma survivors that he personally believes are good for their overall health. These include:

Eating foods rich in anti-oxidants, such as legumes, kale, green leafy vegetables, carrots, fish (especially salmon), fruits, whole grains, and flax seed.
Taking recommended daily doses of anti-oxidant supplements, including beta carotene, selenium, vitamin C, vitamin E and fish oils (also known as EPA).
Drink one to two glasses of red wine a day. Resveratrol, a polyphenol found in the skins of grapes (part of the plant's immune system), has potent anti-cancer properties and becomes concentrated in red wine during the fermentation process.
Avoiding other forms of alcohol other than red wine, as alcohol in general is detrimental to a person's health in many ways and suppresses the immune system.

"I always tell my melanoma patients to remain hopeful and vigilant, and see your dermatologist regularly," added Dr. Rogers. "Even if you beat melanoma once, you have an increased risk of getting another one in the future. With melanoma, you can never let your guard down."

Visit www.melanomamonday.org to find out how to perform a skin self-exam, download a body mole map to track changes in your skin and find free skin cancer screenings in your area. For more information on skin cancer, go to the "SkinCancerNet" section of www.skincarephysicians.com, a Web site developed by dermatologists that provides patients with up-to-date information on the treatment and management of disorders of the skin, hair and nails.

Headquartered in Schaumburg, Ill., the American Academy of Dermatology (Academy), founded in 1938, is the largest, most influential, and most representative of all dermatologic associations. With a membership of more than 15,000 physicians worldwide, the Academy is committed to: advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education, and research in dermatology; and supporting and enhancing patient care for a lifetime of healthier skin, hair and nails. For more information, contact the Academy at 1-888-462-DERM (3376) or www.aad.org.

Source: American Academy of Dermatology

http://www.dermahealthinstitute.com